Spondylolisthesis Isthmic

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Anatomical Features The pars interarticularis, or isthmus as it is commonly known, is the portion of the neural arch that connects the lamina with the pedicle, facet joints, and transverse process. As such, this is a key component in segmental integrity. A spondylolisthetic defect in the pars interarticularis may lead to a VB subluxation; this is known as isthmic spondylolisthesis.13 Three subtypes of the isthmic spondylolisthesis are recognized. Subtype A refers to the classic lytic lesion of the pars indicative of a stress fracture. Subtype B indicates an elongated but intact isthmus; this is thought to represent a healed fracture. Subtype C refers to an acute fracture of the pars interarticularis and is the rarest of the subtypes. The authors of cadaveric and mechanical studies have shown that because of its shape and location, the pars interarticularis is subjected to the greatest force of any structure in the lumbar spine; regrettably, these same authors have suggested that the pars interarticularis is the weakest part of the neural arch.10,13,14,29,31 A lytic defect of the pars interarticularis at any given level allows for separation of that VB from its inferior facet, thus allowing the vertebra to slip forward. Over time, this deformity may remain stable or progress. In addition, the anterior subluxation of the spine places stress upon the adjacent disc, leading to progressive disc degeneration. The most common site of isthmic spondylolisthesis is at the L5–S1 level because of an L-5 pars defect. It has been estimated that this pars abnormality is at L-5 in 90% of cases, L-4 in 5%, and other areas in the remaining cases

Origin of Isthmic Spondylolisthesis Isthmic spondylolisthesis has a multifactorial origin; mechanical, hereditary, and hormonal factors are all believed to play a role. Both gravitational and postural forces, acting upon the upright spine, place stress on the pars interarticularis, making it susceptible to injury. It has been shown that fatigue fractures develop in response to cyclic flexion–extension, axial, and rotational loading. In the setting of predisposing factors, repetitive trauma can lead to microfractures of the pars. At times, these fractures heal; at other times, a fibrous union, consisting of fibrocartilaginous tissue is formed. Typically, this fibrous union is weaker than bone; it responds to further stress across the pars by lengthening.7,10,27,29,31 Although the genetic basis of isthmic spondylolisthesis is unknown, one possibility can be inferred from the high incidence of the disease in near relatives of those with isthmic spondylolisthesis. Whereas the incidence of spondylolisthesis is 4 to 8% in the general population, the reported incidence in near relatives is approximately 25 to 30%.18,27,29,30 Progression of the vertebral slippage has been noted during adolescence; whether this implicates hormonal influences or growth potential as factors in the development of spondylolisthesis in uncertain.18,27,29,30 Taking these factors into account, it appears that a congenital predisposition to spondylolysis, in the setting of repeated injury to the pars, is responsible for the development of isthmic spondylolisthesis. Epidemiological Features Identified only in humans, spondylolisthesis has never been recognized in any other species. In humans, the earliest report of a pars defect was in a 3.5-month-old infant; typically, spondylolisthesis is not observed in newborns. It is believed that the development of spondylolisthesis is related to man’s ability to maintain an erect posture and the development of lumbar lordosis, the latter being unique to humans.24,31 Of the different types of spondylolisthesis, the isthmic variety, as well as the dysplastic and degenerative types, is the most common. The incidence of spondylolisthesis in the general adult population is 4 to 8%, varying depending on the race, age, and sex of the population sample. As expected, the incidence of spondylolysis is higher than that of spondylolisthesis; roughly 50% of pars defects give rise to VB subluxation. Reported incidence of spondylolysis ranges from 4.4 to 5.8%; that of isthmic spondylolisthesis ranges from 2.6 to 4.4%. There are two peaks in the temporal presentation of isthmic spondylolisthesis—one occurring between the ages of 5 and 7 years and a second occurring in the teenage years.1,8,10,28,29 With regard to sex, isthmic spondylolisthesis occurs twice as often in males as females. Females, however, are fourfold more likely to suffer progression of the slippage. In general, the higher-grade slippages ( Meyerding Grade I) have the highest risk of progressive deformity. Additionally, congenital anomalies, such as spina bifida occulta, that cause the absence of or hypoplastic posterior elements, can increase the stress transmitted to the pars, leading to its injury and subsequent deformity. This situation is not trivial; in anywhere from 24 to 70% of isthmic spondylolisthesis cases, associated spina bifida occulta may be present.10,18,25,27 In one prospective radiographic study of 500 patients, the authors found a pars defect in 4.4% of 6-year-old children and in 6% of adults. The L-5 vertebra was the most common level to be defective; 90% of abnormalities were discovered at this site. Of the 27 L-5 pars defects, 21 were bilateral; the majority of these patients harboring these defects developed spondylolisthesis. The authors also reported that in 30% of patients with a pars defect, a spina bifida occulta was present at the same level.8 It is well accepted that in young athletes, specifically gymnasts and weight lifters, the mean incidence of pars defects is higher. It has been postulated that repetitive forces of flexion, hyperextension, and rotation required in such athletic activities results in the significant number of pars stress fractures.14 Presenting Signs and Symptoms Although isthmic spondylolisthesis is known to have its onset in childhood, most of those affected do not seek medical attention until later in life. In those adolescents and adults who seek medical evaluation, pain is the typical presenting symptom, usually musculoskeletal or radicular in nature. In approximately half of the cases, there is a history of a precipitating event.11,16,28 The musculoskeletal pain is a deep ache localized to the lumbar area, occasionally radiating into the buttocks or posterior thighs. Typically weight bearing and lifting exacerbate the pain, whereas rest and recumbency relieve it. This pain is often attributed to vertebral instability or pseudarthrosis at the level of the spondylolisthesis. In other situations, the lumbar pain may be discogenic in origin, secondary to adjacent-disc degeneration. Radicular pain is typically caused by irritation, compression, or tension of the L-5 nerve root. Both uni- and bilateral symptoms may be seen. In spondylolysis, the L-5 nerve root may be compressed by fibrocartilaginous scar tissue appearing in the area of the pars defect. Rarely, the intervertebral foramen can be compromised by a degenerated, herniated disc or by the subluxation. In higher-grade subluxations, there can be traction of the cauda equina over the sacrum, leading to signs and symptoms of cauda equina compromise. In this setting, S-1-related symptoms, as well as perineal numbness and sphincter disturbances, may manifest. In younger patients with higher-grade subluxations, deformity may precipitate medical evaluation. On physical examination, this can be appreciated as a palpable stepoff. In isthmic spondylolisthesis in which the defect affects L-5, the L-5 neural arch of remains stationary with respect to the sacrum, whereas the L-4 neural arch slides anteriorly with the L-5 VB. As such, the abnormality is palpated at the L4–5 junction. In mild cases of spondylolisthesis (Meyerding Grade I), the L5–S1 subluxation occurs without any disruption of the normal relationship of the VBs; the subluxation is merely a uniplanar translation. In cases in which the subluxation is 50% or greater, the translation of L-5 on S-1 is also accompanied by an angular displacement, essentially creating a lumbosacral kyphosis. To maintain global sagittal balance, the patient compensates by two maneuvers: hyperextension of the lumbar spine and rotation of the pelvis such that the sacrum is vertical; flexion of the knees and hips also assists in maintaining balance. High-grade spondylolisthesis is also associated with hamstring tightness, which is best described as a muscle spasm of the posterior thighs associated with a fixed flexion of the hip joints and knees. Because electromyographic and neurological abnormalities are absent, most physicians do not believe that there is a neurological basis for the hamstring tightness; rather, the tight hamstring syndrome once again represents the patient’s attempt to maintain sagittal balance.2,3 Imaging Characteristics Radiographic assessment of spondylolisthesis begins with standard plain radiographs that include lateral, anteroposterior, and oblique views. Thirty-degree oblique cranial tilt x-ray films may be more sensitive than traditional oblique x-ray films for demonstrating spondylolysis; the abnormality is classically described as a fracture of “the Scottie dog’s neck” (Fig. 1). Although not routinely obtained, dynamic radiographs such as the hyperextension and -flexion views can highlight occult mobility, if present. Modern CT scanning, with its ability to provide multiplanar reformatting, has largely replaced tomography for delineation of osseous anatomy. Additional studies, such as MR imaging and myelography are of benefit in defining the neural elements; these studies provide information regarding the need for decompression and/or fusion (Fig. 2). Bone scanning may be helpful in determining the age of a lysis, with acute lesions demonstrating increased contrast uptake on examination. Several methods exist for radiographically characterizing the degree of spondylolisthesis. The most common is the Meyerding classification in which the degree of subluxation is described as the percentage of translation of the upper VB over the lower one. The categories include Grade I (0–25% subluxation), Grade II (25–50% subluxation), Grade III (50–75% subluxation), and Grade IV (75% subluxation).16,17 Complete or 100% spondylolisthesis is termed spondyloptosis (Fig. 3). Whereas the Meyerding classification only takes into account translational subluxation, other measurements take into account the angular displacement that can occur in spondylolisthesis. The “slip angle” or sagittal rotation measures the degree of lumbosacral kyphosis. This is calculated by measuring the angle formed by the intersection of two lines: 1) a tangent to a line drawn along the posterior aspect of the sacrum; and 2) a line parallel to the inferior endplate of L-5. In the normal situation, the angle formed by the intersection of these two lines measures zero. The “tilt” or sacral inclination refers to the vertical position of the sacrum, which is measured by drawing a line perpendicular to the floor and measuring the angle formed by the intersection of this line with a second one drawn parallel to the posterior aspect of the sacrum. Usually this angle should be greater than 30°; as the sacrum obtains a more vertical position, this angle becomes progressively smaller.

Management Strategies Nonoperative. Most patients who present with spondylolisthesis are asymptomatic; however, in the pediatric and adolescent population, spondylolisthesis is the predominant cause of low-back pain and sciatica. Nevertheless, nonoperative treatment is successful in the majority of cases, with surgical intervention being reserved for those in whom symptoms are refractory to these measures. Conservative measures include nonsteroidal medications, selective nerve/pars injections, brace therapy, restriction of athletic activities, and bed rest. Typically, these restrictions may be relaxed as symptoms improve. Regardless of whether the pars defect heals, most patients experience resolution of symptoms over time. In one study, 82 adolescents with symptomatic spondylolysis or spondylolisthesis were treated nonoperatively. In a follow-up period of 1 to 14.3 years, only 25 patients required surgical treatment for pain. Of those with Meyerding Grade I or II subluxation, resolution of pain occurred in approximately 70% after conservative therapies.22 Operative. It is the minority of patients who, after nonoperative treatment fails, require surgical intervention. In general, children with spondylolysis and spondylolisthesis respond well to conservative measures; however, this is the population that presents with either high-grade subluxation or progression of dislocation requiring intervention. Typically, the surgery-related results tend to be better in this group compared with those in the adult population. In evaluating a patient with isthmic spondylolisthesis, the course of the disease in the absence of surgical treatment, the potential for progression, and the results of operative treatment must all be considered. Widely accepted criteria for surgical intervention include: 1) persistence of pain or neurological symptoms despite an adequate course of nonoperative treatment;4,12,15 2) progression of slippage greater than 30%;4,14 3) presentation with greater than Grade II subluxation;4,11and 4) cosmetic deformity secondary to postural and gait difficulties.11 Once it is established that conservative treatment has failed, the next step is to determine a surgical plan. Operative interventions include any of the following: decompression, in situ fusion, instrument-assisted fusion, and reduction surgery. Decompression. In adults in whom only radicular symptoms are present, neural decompressive surgery can be performed. As described in 1955, this removal of loose posterior elements and cartilaginous tissue is known as the “Gill procedure.”9 Its drawback is the potential for increasing the subluxation postoperatively. In one study, however, the reported 23% incidence of postoperative subluxation did not preclude a good clinical outcome.20 In children, decompressive surgery is rarely indicated; in situ stabilization has been shown to be effective in resolving neural symptoms; resection of posterior elements carries an unacceptable risk of inducing vertebral column instability. Bone Fusion. In patients with axial low-back pain or progressive spondylolisthesis, noninstrumented fusion of the lumbar spine may be useful. Although bone fusion can be performed using a number of different methods (anterior interbody, posterior interbody, transforaminal interbody, or intertransverse), it is the latter (intertransverse or transversesacral alar) that makes the most sense mechanically. In the adult patient with concomitant neural symptoms, the posterior approach also allows for neural decompression. In the pediatric patient, radicular symptoms are rarely due to a cartilaginous compression and are, rather, secondary to the mechanical movement of the unstable element. Typically, immobilization of the involved segment leads to resolution of the neural symptoms.9,12 Reported results for in situ (intertransverse) fusion indicate that relief of pain can be achieved in both adolescent and adult patients. Pizzutillo, et al.,23 have reported on 40 adolescent patients who underwent posterolateral fusion; resolution of neurological and pain-related symptoms occurred in all.23 In only two of these patients did progression of subluxation occur postoperatively. In a later series, eight adult patients with isthmic spondylolisthesis were treated in a similar manner; in a follow-up period of 2 to 14 years, excellent relief of both radiculopathy and lowback pain was demonstrated in all patients. In addition, all eight patients returned to their previous occupations.21 Instrument-Assisted Fusion. Spinal instrumentation is typically used to improve arthrodesis rates, to repair a pars defect directly, or to reduce the dislocation in high-grade spondylolisthesis. Specifically, pedicle screw fixation devices have been shown to be mechanically superior to other stabilization systems in the lumbar spine. Comparedwith other devices, they allow for the selective segmental application of force to the spinal cord without the need for extension to adjacent levels26 (Fig. 4). In the pediatric population, spinal instrumentation is placed for either direct repair of the pars defect or for reduction of the high-grade subluxation. For Meyerding Grade I lesion, direct repair can be performed by passing a wire around the transverse and spinous processes of the affected level5 or by placing a screw through the lamina and pars defect into the pedicle. Bone grafting of the defect is performed in conjunction with the repair. The benefit of the direct repair procedure is that it preserves motion of the involved motion segment, decreasing stress placed on adjacent levels. This procedure, however, should only be performed in the setting of the low-grade subluxation (Grade I or lower).19 Surgeons who advocate performing reduction surgery in patients with high-grade subluxations reduction list correction of deformity and spinal realignment as a means to achieve higher fusion rates and reduce progression of the dislocation. In this setting, anterior interbody fusion can be used both to release the spine and obtain maximum surface for fusion. With significant relief of pain and neurological symptoms reported after conducting intertransverse fusions, however, it is difficult to appreciate the benefit of reduction surgery. Risks are considerable, with postreduction neural deficits approaching 20%.6 CONCLUSIONS Spondylolisthesis is best treated by understanding the underlying origins of the deformity. In those patients with isthmic spondylolisthesis, nonoperative treatment is successful in the majority of cases. In those with symptoms refractory, to conservative therapies, surgical intervention can be successful in alleviating symptoms (Figs. 5 and 6). Careful correlation of the clinical picture with neuroimaging data will allow for an accurate understanding of the structural issues and will help in the surgery-related decision-making process.

What Is Adult Isthmic Spondylolisthesis?
The spine is made up of a series of connected bones called “vertebrae.” In about 5% of the adult population, there is a developmental crack in one of the vertebrae, usually at the point at which the lower (lumbar) part of the spine joins the tailbone (sacrum). It may develop as a stress fracture. Because of the constant forces the low back experiences, this fracture does not usually heal as normal bone. This type of fracture (called a spondylolysis) is simply a crack in part of the vertebra (Figure 1) and may cause no problem at all. However, sometimes the cracked vertebra does slip forward over the vertebra below it. This is known as adult isthmic spondylolisthesis.

(Another type of spondylolisthesis is degenerative spondylolisthesis, in which slippage develops as a result of arthritis of the small joints of the spine and degeneration of the discs.)

What Are the Symptoms?
Isthmic spondylolisthesis may not cause any symptoms for years (if ever) after the slippage
has occurred. If you do have symptoms, they may include low back and buttocks pain; numbness,
tingling, pain, muscle tightness or weakness in the leg (sciatica); increased sway back; or a
limp. These symptoms are usually aggravated by
standing, walking and other activities, whereas
rest will provide temporary relief

Studies have shown that 5-10% of patients seeing a spine specialist for low back pain will have either a spondylolysis or isthmic spondylolisthesis. However, because isthmic spondylolisthesis is not always painful, the presence of a crack (spondylolysis) and slip (spondylolisthesis) on an X-ray image does not mean that this is the source of your symptoms.

How Is it Diagnosed?
resonance imaging (MRI) study may be ordered to clearly show the soft tissue structures of the spine (including the nerves and discs between the vertebrae) and their relationship to the cracked vertebra and any slippage. It also will show whether any of the nearby discs have suffered any wear and tear because of the spondylolisthesis (slippage).

If isthmic spondylolisthesis is present, it can be graded as I, II, III or IV (Figure 2) based on how far forward the vertebra has slipped.

What Treatments Are Available?
If your doctor determines that a spondylolisthesis is causing your pain, he or she will usually try nonsurgical treatments at first. These treatments may include a short period of rest, anti-inflammatory medications (orally or by injection) to reduce the swelling, analgesic drugs to control the pain, bracing for stabilization, and physical therapy and exercise to improve your strength and flexibility so you can return to a more normal lifestyle. If you are told to rest, follow your doctor’s directions on how long to stay in bed. Generally, if recommended at all, this would be limited to a few days. (Strict bed rest is usually not necessary.) Ask your doctor whether you should continue to work while you are being treated.

Your doctor may also—sometimes with the help of a nurse or physical therapist—begin education
and training in performing activities of daily living without placing added stress on your lower

If a combination of medication and therapy fails to provide relief, however, your doctor may
order additional tests, which will provide greater detail so he or she can plan further treatment.

Medication and Pain Management
Your doctor may use one medication or a combination of medications as part of your treatment
plan. Medications used to control pain are called analgesics. Most pain can be treated with nonprescription medications like aspirin, ibuprofen, naproxen or acetaminophen. Some analgesics,
referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are also used to reduce swelling
and inflammation that may occur. These include aspirin, ibuprofen, naproxen and a variety of prescription drugs. If your doctor gives you analgesics or anti-inflammatory medications, you should watch for side effects like stomach upset or bleeding. Chronic use of prescription or
over‑the‑counter analgesics or NSAIDs should be monitored by your physician for the development
of any potential problems.

If you have severe persistent pain that is not relieved by other analgesics or NSAIDs, your
doctor might prescribe narcotic analgesics (such as codeine) for a short time. Take only the
medication amount that is prescribed. Taking a larger dosage doesn’t help you recover faster.
Side effects include nausea, constipation, dizziness and drowsiness, and use can result in dependency. All medication should be taken only as directed. Make sure you tell your doctor about any kind of medication you are taking—even over‑the‑counter drugs—and inform your doctor
about whether your medication is working for you.

Other anti-inflammatory medications such as corticosteroid (oral or by injection) are sometimes prescribed for more severe back and leg pain because of their very powerful anti-inflammatory effect. Corticosteroids, like NSAIDs, can have side effects. Risks and benefits of this medication should be discussed with your physician.

Selected spinal injections, or “blocks,” may be used to relieve symptoms of pain. These are
injections of corticosteroid into the epidural space (the area around the spinal nerves) or facet joint (between vertebrae) performed by a doctor with special training in this technique. The initial injection may be followed by one or two more injections at a later date. These are most often done as part of a comprehensive rehabilitation and treatment program.

Nonsurgical Treatment
As you begin a physical therapy regimen and/ or exercise program, your doctor may prescribe
therapies like ultrasound, electric stimulation, hot packs, cold packs and manual “hands on”
therapy to reduce your pain and muscle spasms. At first, the exercises you learn may be gentle
stretches or posture changes to reduce the back pain or leg symptoms. When you have less pain,
more vigorous aerobic exercises (such as stationary bicycling or swimming) combined with
strengthening/stretching exercises will likely be used to improve flexibility, strength, endurance and the ability to return to a more normal lifestyle. Developing your back and stomach
muscles will help stabilize your spine and support your body. Exercise instruction should start right away and be modified as recovery progresses. Learning and continuing an exercise and
stretching program are also important parts of treatment, as is maintaining a reasonable body

The presence of this “cracked vertebra” (spondylolysis) or “slippage” (spondylolisthesis) by
itself usually does not represent a dangerous condition in the adult. Therefore, treatment is aimed at pain relief and increasing the patient’s ability to function. Although none of the nonsurgical treatments will correct the “crack” or “slippage,” they can provide long‑lasting pain control without requiring more invasive treatment. A comprehensive program may require three or more months of supervised treatment.

What if I Need Surgery?
Surgery is reserved for the small percentage of patients whose pain cannot be relieved by nonsurgical treatment. The pain may be caused by a pinched nerve, movement of the unstable cracked vertebra, or from nearby discs. If a spinal nerve is being compressed by the forward slip, surgery may be needed to reopen a “tunnel,” or space, for the nerve.

In addition to relieving pressure on a nerve around the crack or slippage, a stabilizing procedure or fusion may be recommended. This will stop any further slippage of the vertebra and
also will prevent recurrent nerve pressure from developing at this site. The success rate of fusion surgery in relieving symptoms of isthmic spondylolisthesis is over 75%.

Occasionally the the vertebra can be repaired by placing bone graft at the site of the crack. A fusion can be performed from the front (anterior approach) or the back (posterior approach). Both require the placement of bone graft or bone graft substitute and/or instrumentation between the vertebrae being fused. The choice of approach (front vs back) depends on many technical factors including need for spur removal, location of the spurs, the patient’s unique anatomy and the experience of the surgeon.

How soon you can return to work partially depends on your job. If you spend most of the
time at a desk, you may be able to return as early as two to three weeks after surgery. If your job is physically demanding, you may have to wait for the bones to fuse or heal, which may take several months. A thorough postoperative rehabilitation program is recommended to help you resume the normal activities of daily living.